Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis

@article{Geraldo2008TargetingOT,
  title={Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis},
  author={Sara Geraldo and Umme K. Khanzada and Maddy Parsons and John K Chilton and Phillip R. Gordon-Weeks},
  journal={Nature Cell Biology},
  year={2008},
  volume={10},
  pages={1181-1189}
}
Interactions between dynamic microtubules and actin filaments (F-actin) underlie a range of cellular processes including cell polarity and motility. In growth cones, dynamic microtubules are continually extending into selected filopodia, aligning alongside the proximal ends of the F-actin bundles. This interaction is essential for neuritogenesis and growth-cone pathfinding. However, the molecular components mediating the interaction between microtubules and filopodial F-actin have yet to be… CONTINUE READING
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