Targeting of stress response pathways in the prevention and treatment of cancer.

@article{Zelenka2018TargetingOS,
  title={Targeting of stress response pathways in the prevention and treatment of cancer.},
  author={Jaroslav Zelenka and Martina Konco{\vs}ov{\'a} and Tom{\'a}{\vs} Ruml},
  journal={Biotechnology advances},
  year={2018},
  volume={36 3},
  pages={
          583-602
        }
}
The hallmarks of tumor tissue are not only genetic aberrations but also the presence of metabolic and oxidative stress as a result of hypoxia and lactic acidosis. The stress activates several prosurvival pathways including metabolic remodeling, autophagy, antioxidant response, mitohormesis, and glutaminolysis, whose upregulation in tumors is associated with a poor survival of patients, while their activation in healthy tissue with statins, metformin, physical activity, and natural compounds… CONTINUE READING
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