Targeting of sonic hedgehog-Gli signaling: A potential therapeutic target for patients with breast cancer.

@article{Song2016TargetingOS,
  title={Targeting of sonic hedgehog-Gli signaling: A potential therapeutic target for patients with breast cancer.},
  author={Lingqin Song and Weifeng Wang and Di Liu and Yang Zhao and Jianjun He and Xijing Wang and Zhijun Dai and Huimin Zhang and Xiao Li},
  journal={Oncology letters},
  year={2016},
  volume={12 2},
  pages={
          1027-1033
        }
}
Breast cancer is the most common malignant cancer among women. The Hedgehog (Hh) signaling pathway serves a key role in malignant cancer cell growth and migration. However, little is known with regard to the specific function of the Hh signaling pathway in human breast cancer. The current study investigated the specific role of Hh signaling in the human breast cancer cell line MDA-MB-231. Expression of components of Shh-Gli signaling, as well as the Gli-responsive genes B-cell lymphoma 2 (Bcl-2… CONTINUE READING
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