Targeting of piperine intercalated in mannose-coated liposomes in experimental leishmaniasis.

  title={Targeting of piperine intercalated in mannose-coated liposomes in experimental leishmaniasis.},
  author={B Raay and Stefania Medda and Sibabrata Mukhopadhyay and Mukul Kumar Basu},
  journal={Indian journal of biochemistry & biophysics},
  volume={36 4},
The leishmanicidal property of piperine intercalated in liposomes and in mannose-coated liposomes was tested in experimental visceral leishmaniasis in hamsters. Mannose-coated liposomal piperine eliminated intracellular amastigotes of Leishmania donovani in splenic macrophages much more efficiently than did the liposomal piperine or free piperine. At a dose equivalent to 6 mg/kg body wt every 4th day for a total of 4 doses in 12 days, the mannose-coated liposomal piperine was found to reduce… CONTINUE READING

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Exptl Parasitol 66

B GBhat, N Chandrasekharan
J Ethanopharmacol • 1987

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