Targeting of p32 in peritoneal carcinomatosis with intraperitoneal linTT1 peptide-guided pro-apoptotic nanoparticles.

@article{Hunt2017TargetingOP,
  title={Targeting of p32 in peritoneal carcinomatosis with intraperitoneal linTT1 peptide-guided pro-apoptotic nanoparticles.},
  author={Hedi Hunt and Lorena Sim{\'o}n-Gracia and Allan Tobi and Venkata Ramana Kotamraju and Sankalp Sharma and Mait Nigul and Kazuki N. Sugahara and Erkki Ruoslahti and Tambet Teesalu},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2017},
  volume={260},
  pages={
          142-153
        }
}
Gastrointestinal and gynecological malignancies disseminate in the peritoneal cavity - a condition known as peritoneal carcinomatosis (PC). Intraperitoneal (IP) administration can be used to improve therapeutic index of anticancer drugs used for PC treatment. Activity of IP anticancer drugs can be further potentiated by encapsulation in nanocarriers and/or affinity targeting with tumor-specific affinity ligands, such as tumor homing peptides. Here we evaluated a novel tumor penetrating peptide… CONTINUE READING
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