Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.

@article{Borger2006TargetingOP,
  title={Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.},
  author={Darrell R. Borger and James A. DeCaprio},
  journal={Journal of virology},
  year={2006},
  volume={80 9},
  pages={4292-303}
}
The primary transforming functions of simian virus 40 large T antigen (SV40 LT) are conferred primarily through the binding and inactivation of p53 and the retinoblastoma family members. Normal p53 function requires an association with the CREB binding protein (CBP)/p300 coactivators, and a ternary complex containing SV40 LT, p53, and CBP/p300 has been identified previously. In this report, we have evaluated a secondary function of p53 bound to the SV40 LT complex in mediating the binding of… CONTINUE READING

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