Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity

Abstract

Multiple myeloma (MM) cells induce relevant angiogenic effects within the human bone marrow milieu (huBMM) by the aberrant expression of angiogenic factors. Hypoxia triggers angiogenic events within the huBMM and the transcription factor hypoxia-inducible factor-1α (HIF-1α) is over-expressed by MM cells. Since synthetic miR-199a-5p mimics negatively… (More)

Topics

5 Figures and Tables

Cite this paper

@inproceedings{Raimondi2014TargetingOM, title={Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity}, author={Lavinia Raimondi and Nicola Amodio and Maria Teresa Di Martino and Emanuela Altomare and Marzia Leotta and Daniele Caracciolo and Annamaria Gull{\`a} and Antonino Neri and Simona Taverna and Patrizia D'Aquila and Riccardo Alessandro and Antonio Giordano and Pierosandro Tagliaferri and Pierfrancesco Tassone}, booktitle={Oncotarget}, year={2014} }