Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle.

@article{Ernsting2015TargetingOM,
  title={Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle.},
  author={M. J. E. Ernsting and Bryan T Hoang and Ines Lohse and Elijus Undzys and Pinjiang M. Cao and Trevor Do and Bethany Gill and Melania Pintilie and David Hedley and Shyh-Dar Li},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2015},
  volume={206},
  pages={
          122-30
        }
}
Pancreatic ductal adenocarcinomas are characterized by the desmoplastic reaction, a dense fibrous stroma that has been shown to be supportive of tumor cell growth, invasion, and metastasis, and has been associated with resistance to chemotherapy and reduced patient survival. Here, we investigated targeted depletion of stroma for pancreatic cancer therapy via taxane nanoparticles. Cellax-DTX polymer is a conjugate of docetaxel (DTX), polyethylene glycol (PEG), and acetylated… CONTINUE READING
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