Targeting of heat-shock protein 32/heme oxygenase-1 in canine mastocytoma cells is associated with reduced growth and induction of apoptosis.

@article{Hadzijusufovic2008TargetingOH,
  title={Targeting of heat-shock protein 32/heme oxygenase-1 in canine mastocytoma cells is associated with reduced growth and induction of apoptosis.},
  author={Emir Hadzijusufovic and Laura Rebuzzi and Karoline V. Gleixner and Veronika Ferenc and Barbara Peter and Rudin Kondo and Alexander Gruze and Michael Kneidinger and M. Krauth and Matthias Mayerhofer and Puchit Samorapoompichit and Khaled Greish and Arun K Iyer and Winfried F. Pickl and Hiroshi Maeda and Michael Willmann and P. Valent},
  journal={Experimental hematology},
  year={2008},
  volume={36 11},
  pages={
          1461-70
        }
}
OBJECTIVE Advanced mast cell (MC) neoplasms are usually resistant to conventional therapy. Therefore, current research focuses on new targets in neoplastic MC and development of respective targeted drugs. Mastocytomas in dogs often behave as aggressive tumors. We report that heat-shock protein 32 (Hsp32), also known as heme oxygenase-1, is a survival-enhancing molecule and new target in canine mastocytoma cells. MATERIALS AND METHODS As assessed by reverse transcriptase polymerase chain… CONTINUE READING