Targeting of green fluorescent protein to secretory granules in oxytocin magnocellular neurons and its secretion from neurohypophysial nerve terminals in transgenic mice.

@article{Zhang2002TargetingOG,
  title={Targeting of green fluorescent protein to secretory granules in oxytocin magnocellular neurons and its secretion from neurohypophysial nerve terminals in transgenic mice.},
  author={Bingchang Zhang and Kiyoshi Kusano and Patricia M. Zerfas and Anna L. Iacangelo and W Scott Young and Harold Gainer},
  journal={Endocrinology},
  year={2002},
  volume={143 3},
  pages={
          1036-46
        }
}
Oxytocin (OT) is a hypothalamic nonapeptide that is synthesized as part of a larger precursor protein that also contains an approximately 10-kDa protein called neurophysin at its C-terminus. This precursor protein is trafficked through the regulated secretory pathway into secretory granules and then axonally transported to and secreted from nerve terminals in the neural lobe of the pituitary. In this paper, we show that the AI-03 transgene that contains enhanced green fluorescent protein (EGFP… CONTINUE READING
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