Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells.

@article{Lynn2015TargetingOF,
  title={Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells.},
  author={Rachel Christina Lynn and Mathilde A. Poussin and Anna Kalota and Yang Feng and Philip S Low and D. S. Dimitrov and Daniel James Powell},
  journal={Blood},
  year={2015},
  volume={125 22},
  pages={
          3466-76
        }
}
T cells expressing a chimeric antigen receptor (CAR) can produce dramatic results in lymphocytic leukemia patients; however, therapeutic strategies for myeloid leukemia remain limited. Folate receptor β (FRβ) is a myeloid-lineage antigen expressed on 70% of acute myeloid leukemia (AML) patient samples. Here, we describe the development and evaluation of the first CARs specific for human FRβ (m909) in vitro and in vivo. m909 CAR T cells exhibited selective activation and lytic function against… CONTINUE READING
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A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer

  • LE Kandalaft, DJ Powell, Jr., G. Coukos
  • J Transl Med
  • 2012

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