Targeting of cytotoxic somatostatin analog AN-238 to somatostatin receptor subtypes 5 and/or 3 in experimental pancreatic cancers.

@article{Szepeshzi2001TargetingOC,
  title={Targeting of cytotoxic somatostatin analog AN-238 to somatostatin receptor subtypes 5 and/or 3 in experimental pancreatic cancers.},
  author={Karoly Szepesh{\'a}zi and Andrew V Schally and G{\'a}bor Halmos and Baodong Sun and Francine E Hebert and Bal{\'a}zs Csernus and Attila Nagy},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2001},
  volume={7 9},
  pages={2854-61}
}
PURPOSE The expression of somatostatin receptors (SSTRs) allows the localization and treatment of some tumors with radiolabeled SST analogues. We investigated whether SSTRs on human pancreatic cancer lines xenografted into nude mice can be used for targeting of cytotoxic somatostatin analogue AN-238, consisting of 2-pyrrolinodoxorubicin (AN-201) linked to… CONTINUE READING