Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

@inproceedings{VarelaEirn2018TargetingOC,
  title={Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis},
  author={Marta Varela-Eir{\'i}n and Adri{\'a}n Varela-V{\'a}zquez and Amanda Guiti{\'a}n-Caama{\~n}o and Carlos Luis Pa{\'i}no and Virginia Mato and Raquel Largo and Trond Aasen and Arantxa Tabernero and Eduardo Fonseca and Mustapha Kandouz and Jos{\'e} Ram{\'o}n Caeiro and Alfonso Blanco Blanco and Maria Dolores May{\'a}n},
  booktitle={Cell Death & Disease},
  year={2018}
}
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression. Similar to other wound-healing disorders, chondrocytes from OA patients show a chronic increase in the gap junction channel protein connexin43 (Cx43), which regulates signal transduction through the exchange of… CONTINUE READING
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