Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses

@article{Lasaro2008TargetingOA,
  title={Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses},
  author={Marcio O. Lasaro and N. C. Tatsis and Scott E Hensley and J. Charles Whitbeck and Shih-wen Lin and John J. Rux and E John Wherry and Gary H Cohen and Roselyn J Eisenberg and Hildegund C J Ertl},
  journal={Nature Medicine},
  year={2008},
  volume={14},
  pages={205-212}
}
Interactions between the herpesvirus entry mediator (HVEM) and the B- and T-lymphocyte attenuator (BTLA) inhibit B and T cell activation. HVEM-BTLA interactions are blocked by herpes simplex virus (HSV) glycoprotein D (gD) through binding of its N-terminal domain to the BTLA binding site of HVEM. In this study, we inserted viral antigens into the C-terminal domain of gD and expressed these antigens with plasmid or E1-deleted (replication-defective) adenovirus vectors. Viral antigens fused to gD… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES