Targeting of adenovirus to endothelial cells by a bispecific single-chain diabody directed against the adenovirus fiber knob domain and human endoglin (CD105).

@article{Nettelbeck2001TargetingOA,
  title={Targeting of adenovirus to endothelial cells by a bispecific single-chain diabody directed against the adenovirus fiber knob domain and human endoglin (CD105).},
  author={Dirk M. Nettelbeck and David W. Miller and Val{\'e}rie J{\'e}r{\^o}me and Michelle Cristina Luis Zuzarte and Shanea J. Watkins and Robert Edward Hawkins and Roswitha Mueller and Roland E Kontermann},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2001},
  volume={3 6},
  pages={
          882-91
        }
}
The use of adenoviruses for antivascular cancer gene therapy is limited by their low transduction efficiency for endothelial cells. We have developed a recombinant bispecific antibody as a molecular bridge, linking the adenovirus capsid to the endothelial cell surface protein endoglin, for vascular targeting of adenoviruses. Endoglin (CD105), a component of the transforming growth factor beta receptor complex, represents a promising target for antivascular cancer therapy. Endoglin is expressed… CONTINUE READING

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