Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse.

@article{Rivas2011TargetingOA,
  title={Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse.},
  author={Elisa Isabel Rivas and John P Driver and Nahir Garabatos and Maximiliano Presa and Conchi Mora and Fernando Morgado Rodr{\'i}guez and David V Serreze and Thomas Stratmann},
  journal={Journal of immunology},
  year={2011},
  volume={186 7},
  pages={
          4078-87
        }
}
CD4 T cells are crucial effectors in the pathology of type 1 diabetes (T1D). Successful therapeutic interventions for prevention and cure of T1D in humans are still elusive. Recent research efforts have focused on the manipulation of T cells by treatment with DNA. In this paper, we studied the effects of a DNA treatment strategy designed to target antigenic peptides to the lysosomal compartment on a monospecific T cell population termed 2.5mi(+) T cells that shares reactivity with the… CONTINUE READING
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