Targeting of Rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assembly.

@article{Gorzalczany2000TargetingOR,
  title={Targeting of Rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assembly.},
  author={Yara Gorzalczany and Natalia Sigal and M Itan and Ofra Lotan and Edgar Pick},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 51},
  pages={40073-81}
}
The superoxide (O(2))-generating NADPH oxidase complex of phagocytes consists of a membrane-associated flavocytochrome (cytochrome b(559)) and four cytosolic proteins, p47(phox), p67(phox), p40(phox), and the small GTPase Rac (Rac1 or -2). NADPH oxidase activation (O(2) production) is elicited as the consequence of assembly of some or all cytosolic components with cytochrome b(559). This process can be reproduced in an in vitro system consisting of phagocyte membranes, p47(phox), p67(phox), and… CONTINUE READING

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