Targeting of Proteins of the Striatin Family to Dendritic Spines: Role of the Coiled‐Coil Domain

  title={Targeting of Proteins of the Striatin Family to Dendritic Spines: Role of the Coiled‐Coil Domain},
  author={Stéphane Gaillard and Yannick Bailly and Marion Benoist and Tatiana V. Rakitina and Jean-Pierre Kessler and Laure Fronzaroli‐Molinieres and B{\'e}n{\'e}dicte Dargent and Francis Castets},
Striatin, SG2NA and zinedin, the three mammalian members of the striatin family are multimodular WD‐repeat, calmodulin and calveolin‐binding proteins. These scaffolding proteins, involved in both signaling and trafficking, are highly expressed in neurons. Using ultrastructural immunolabeling, we showed that, in Purkinje cells and hippocampal neurons, SG2NA is confined to the somatodendritic compartment with the highest density in dendritic spines. In cultured hippocampal neurons, SG2NA is also… 

Immunogold localization of phocein in dendritic spines

The early postnatal expression of phocein, a protein involved in membrane dynamics, suggests that it may have functional relevance in dendritic remodeling during development and potentially in spine plasticity during adulthood.

Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A

The local expression of STRN4 is unraveled as a novel mechanism for the control of dendritic spine morphology and the function of various striatin family members in the neuron remains unknown.

Cortactin-Binding Protein 2 Modulates the Mobility of Cortactin and Regulates Dendritic Spine Formation and Maintenance

The distribution and function of neuron-predominant cortactin-binding protein 2 (CTTNBP2) in rodents is characterized and it is suggested that CTTNBP2 modulates the mobility of Cortactin in neurons.

Phocein: A potential actor in vesicular trafficking at Purkinje cell dendritic spines

This review focuses on immuno-cytochemical studies showing the strict localization of phocein in Purkinje cell dendritic spines involved in excitatory transmission in the cerebellum of postnatal and adult rodents, and co-localization of phecein and SG2NA within spines suggests that their interactions have a functional significance in the molecular cascades that underly membrane trafficking in postsynaptic structures.

Distribution of zinedin in the rat brain

The rostral expression of zinedin as well as its compartmented distribution in dendritic spines may have important implications not only for ziningin function but also in the physiology of dendrite spines of a particular subset of neurons.

The Involvement of Neuron-Specific Factors in Dendritic Spinogenesis: Molecular Regulation and Association with Neurological Disorders

How ubiquitously expressed genes, including syndecan-2, NF1 (encoding neurofibromin protein), VCP, and CASK, and the neuron-specific gene CTTNBP2 coordinate with neurotransmission, transsynaptic signaling, and cytoskeleton rearrangement to control dendritic filopodia formation, filopODia-spines transition, and dendrite spine maturation and maintenance is summarized.

Structure-Function Analysis of Core STRIPAK Proteins

It is proposed that STRIPAK regulates the balance between MST4 localization at the Golgi and in the cytosol to control Golgi positioning and depletion of CCM3 or striatins affects Golgi polarization in an opposite manner.

Among the three striatin family members, SG2NA was first to arise during evolution.

It is hypothesized that striatin family members have evolved from bacteria, and SG2NA was the first member to arise.



Striatin, a calmodulin‐dependent scaffolding protein, directly binds caveolin‐1

Zinedin, SG2NA, and Striatin Are Calmodulin-binding, WD Repeat Proteins Principally Expressed in the Brain*

A phylogenetic analysis supports the hypothesis that zinedin and SG2NA constitute a multigenic family deriving from an ancestral gene and both localize to the soma and dendrites, suggesting that they share a similar type of addressing and closely related functions.

Interaction of Calmodulin with Striatin, a WD-repeat Protein Present in Neuronal Dendritic Spines*

The results are in agreement with the hypothesis that striatin is a transducer involved in Ca2+signaling or an adapter protein involved in regulating macromolecular assemblies within dendritic spines.

Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines.

Immunocytochemical studies of adult rat brain sections showed that phocein reactivity, present in many types of neurons, is strictly somato-dendritic and extends down to spines, just as do striatin and SG2NA.

The postsynaptic density and dendritic raft localization of PSD-Zip70, which contains an N-myristoylation sequence and leucine-zipper motifs

In Madin-Darby canine kidney cells, exogenous PSD-Zip70 was targeted to the apical plasma membrane of microvilli, and its N-myristoylation was necessary for this targeting.

Distribution of Striatin, a newly identified calmodulin‐binding protein in the rat brain: An in situ hybridization and immunocytochemical study

Data show that the somatodendritic localization of striatin, previously described in the striatum, may be a main feature of the subcellular distribution of this protein throughout the CNS.

Signaling between the actin cytoskeleton and the postsynaptic density of dendritic spines

The aim is to catalog many of the known components of hippocampal dendritic spines and suggest how these may contribute to spine function, and to compare dendrite spines with other actin‐based structures to gain some insight into possible common vs. specialized mechanisms of regulation of the shape, motility, and longevity of these actin-based structures.

Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering.

It is demonstrated immunohistochemically that metabotropic glutamate receptor 1alpha and PSD-Zip45/Homer 1c are colocalized to synapses in the cerebellar molecular layer but not in the hippocampus, and the leucine zipper of subsynaptic scaffold protein is a candidate motif involved in neurotransmitter receptor clustering at the central synapse.

WD40 Repeat Proteins Striatin and S/G2 Nuclear Autoantigen Are Members of a Novel Family of Calmodulin-binding Proteins That Associate with Protein Phosphatase 2A*

One mechanism of targeting and organizing PP2A with components of Ca2+-dependent signaling pathways may be through the molecular scaffolding proteins striatin and SG2NA, which are highly related WD40 repeat proteins of previously unknown function and distinct subcellular localizations.

Expression and distribution of phocein and members of the striatin family in neurones of rat peripheral ganglia

This study demonstrates that phocein and the members of the striatin family are expressed not only in central nervous system but also in the peripheral nervous system and, in particular, in afferent sensory neurones.