Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines.

Abstract

Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that trimethylates H3K27, a mark of repressed chromatin. Mammalian PRC2 binds RNA promiscuously, with thousands of target transcripts in vivo. But what does PRC2 recognize in these RNAs? Here we show that purified human PRC2 recognizes G > C,U ≫ A in single-stranded RNA and has a high… (More)
DOI: 10.1016/j.molcel.2017.02.003

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