Targeting of Matrix Metalloproteinase-2 activation with Gd-NBCB-TTDA-MMP-2 for detection of vulnerable atherosclerotic plaques using a novel molecular MR Imaging in vivo

@inproceedings{Jaw2010TargetingOM,
  title={Targeting of Matrix Metalloproteinase-2 activation with Gd-NBCB-TTDA-MMP-2 for detection of vulnerable atherosclerotic plaques using a novel molecular MR Imaging in vivo},
  author={T-S. Jaw and H-L. Wu and G-Y. Shi and Y-M. Wang and G-C. Liu and Y-T. Kuo},
  year={2010}
}
  • T-S. Jaw, H-L. Wu, +3 authors Y-T. Kuo
  • Published 2010
We successfully synthesized and characterized a novel gadolinium-based MR contrast agent, Gd-NBCB-TTDA-MMP-2 , that molecularly targets MMP-2.The aim of this study was to image MMP-2 activity in vivo in atherosclerotic plaques of ApoE -/mice with Gd-NBCB-TTDA-MMP-2 enhanced MRI. Gd-NBCB-TTDA-MMP-2(D), a scrambled form of Gd-NBCB-TTDA-MMP-2, enhanced MRI was also performed as a comparison. Our results showed that Gd-NBCB-TTDA-MMP-2 targeted to MMP-2 facilitated in vivo specific assessment of… CONTINUE READING