Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague.

@article{Do2010TargetingOL,
  title={Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague.},
  author={Yoonkyung Do and Hyein Koh and Chae Gyu Park and Diana Dudziak and Patrick Seo and Saurabh Mehandru and Jae-Hoon Choi and Cheolho Cheong and Steven Y. Park and David Scott Perlin and Bradford S Powell and Ralph Marvin Steinman},
  journal={European journal of immunology},
  year={2010},
  volume={40 10},
  pages={
          2791-6
        }
}
To help design needed new vaccines for pneumonic plague, we targeted the Yersinia pestis LcrV protein directly to CD8α(+) DEC-205(+) or CD8α(-) DCIR2(+) DC along with a clinically feasible adjuvant, poly IC. By studying Y. pestis in mice, we could evaluate the capacity of this targeting approach to protect against a human pathogen. The DEC-targeted LcrV induced polarized Th1 immunity, whereas DCIR2-targeted LcrV induced fewer CD4(+) T cells secreting IFN-γ, but higher IL-4, IL-5, IL-10, and IL… CONTINUE READING
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