Targeting of IL-2 receptor with a caspase fusion protein disrupts autoimmunity in prediabetic and diabetic NOD mice

Abstract

Interruption of IL-2 signalling is an attractive therapeutic target in autoimmune disorders. In this study we evaluated the effect of a fusion protein composed of IL-2 and caspase-3 (IL2–cas) on NOD mice, as compared with disease induction by cyclophosphamide. IL2–cas was assessed in NOD mice at various ages and in conjunction with cyclophosphamide… (More)
DOI: 10.1007/s00125-009-1604-4

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