Targeting of ICAM-1 on vascular endothelium under static and shear stress conditions using a liposomal Gd-based MRI contrast agent

@inproceedings{Paulis2012TargetingOI,
  title={Targeting of ICAM-1 on vascular endothelium under static and shear stress conditions using a liposomal Gd-based MRI contrast agent},
  author={L E Paulis and Israel S. Jacobs and Nynke M. S. van den Akker and Tessa T Geelen and Daniel Molin and Lucas W. E. Starmans and Klaas Nicolay and Gustav J. Strijkers},
  booktitle={Journal of nanobiotechnology},
  year={2012}
}
BACKGROUND The upregulation of intercellular adhesion molecule-1 (ICAM-1) on the endothelium of blood vessels in response to pro-inflammatory stimuli is of major importance for the regulation of local inflammation in cardiovascular diseases such as atherosclerosis, myocardial infarction and stroke. In vivo molecular imaging of ICAM-1 will improve diagnosis and follow-up of patients by non-invasive monitoring of the progression of inflammation. RESULTS A paramagnetic liposomal contrast agent… CONTINUE READING
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