Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein.


Nearly 60% of acute myeloid leukemia (AML) patients with the t(8;21)(q22;q22) translocation fail to achieve long-term disease-free survival. Our previous studies demonstrated that oridonin selectively induces apoptosis of t(8;21) leukemia cells and causes cleavage of AML1-ETO oncoprotein resulting from t(8;21), but the underlying mechanisms remain unclear… (More)
DOI: 10.1126/scitranslmed.3003562


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