Targeting neutrophils in ischemic stroke: translational insights from experimental studies.

  title={Targeting neutrophils in ischemic stroke: translational insights from experimental studies.},
  author={Glen C. Jickling and Dazhi Liu and Bradley P. Ander and Boryana S Stamova and Xinhua Zhan and Frank R. Sharp},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={35 6},
Neutrophils have key roles in ischemic brain injury, thrombosis, and atherosclerosis. As such, neutrophils are of great interest as targets to treat and prevent ischemic stroke. After stroke, neutrophils respond rapidly promoting blood-brain barrier disruption, cerebral edema, and brain injury. A surge of neutrophil-derived reactive oxygen species, proteases, and cytokines are released as neutrophils interact with cerebral endothelium. Neutrophils also are linked to the major processes that… CONTINUE READING
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