Targeting neurotrophin receptors in the central nervous system.

  title={Targeting neurotrophin receptors in the central nervous system.},
  author={Italo Mocchetti and Milton Brown},
  journal={CNS & neurological disorders drug targets},
  volume={7 1},
Neurotrophic factors, and in particular the neurotrophins, restore the function of damaged neurons and prevent apoptosis in adults. The potential therapeutic property of the neurotrophins is however, complicated by the peptidergic structure of these trophic factors, which impairs their penetration into the brain parenchyma, and therefore makes their pharmaco-therapeutic properties difficult to evaluate. In this article we will focus on the neurotrophin Brain-derived neurotrophic factor (BDNF… CONTINUE READING
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