Targeting myeloid cells using nanoparticles to improve cancer immunotherapy.

  title={Targeting myeloid cells using nanoparticles to improve cancer immunotherapy.},
  author={Zohreh Amoozgar and Michael S Goldberg},
  journal={Advanced drug delivery reviews},
While nanoparticles have traditionally been used to deliver cytotoxic drugs directly to tumors to induce cancer cell death, emerging data suggest that nanoparticles are likely to generate a larger impact on oncology through the delivery of agents that can stimulate antitumor immunity. Tumor-targeted nanocarriers have generally been used to localize chemotherapeutics to tumors and thus decrease off-target toxicity while enhancing efficacy. Challengingly, tumor heterogeneity and evolution render… CONTINUE READING
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