Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.

@article{Wang2013TargetingMK,
  title={Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.},
  author={Yuanxiang Wang and Christine E Kaiser and Brendan Frett and Hong-Yu Li},
  journal={Journal of medicinal chemistry},
  year={2013},
  volume={56 13},
  pages={
          5219-30
        }
}
The RAS proteins play a role in cell differentiation, proliferation, and survival. Aberrant RAS signaling has been found to play a role in 30% of all cancers. KRAS, a key member of the RAS protein family, is an attractive cancer target, as frequent point mutations in the KRAS gene render the protein constitutively active. A number of attempts have been made to target aberrant KRAS signaling by identifying small molecule compounds that (1) are synthetic lethal to mutant KRAS, (2) block KRAS/GEF… CONTINUE READING
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