Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes.

@article{Wadhwa2003TargetingMU,
  title={Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes.},
  author={Renu Wadhwa and Hiroshi Ando and Hiroaki Kawasaki and K. Taira and Sunil C. Kaul},
  journal={EMBO reports},
  year={2003},
  volume={4 6},
  pages={595-601}
}
Mortalin, also known as mot2/mthsp70/GRP75/PBP74, is a member of the heat-shock protein 70 family that is heat-uninducible. It is differentially distributed in cells that have normal and immortal phenotypes, has been localized to various subcellular sites, and has several binding partners and functions. Here, we describe the construction and use of mortalin-specific conventional and hybrid ribozymes to elucidate its crucial role in cell proliferation. Whereas conventional hammerhead ribozymes… CONTINUE READING