Targeting monocyte chemoattractant protein-1 signalling in disease.

  title={Targeting monocyte chemoattractant protein-1 signalling in disease.},
  author={Janet Dawson and Wolfgang Miltz and Anis Khusro Mir and Christoph Wiessner},
  journal={Expert opinion on therapeutic targets},
  volume={7 1},
Monocyte chemoattractant protein-1 (MCP-1) has been implicated in many inflammatory and autoimmune diseases. The G-protein-coupled receptor CCR-2B is probably the most important MCP-1 receptor in vivo, and loss of MCP-1 effector function alone is sufficient to impair monocytic trafficking in inflammation models. MCP-1 signalling appears to be a relevant target, especially in rheumatoid arthritis (RA). In RA patients, MCP-1 is produced by synovial cells and infiltrating monocytes, plasma MCP-1… CONTINUE READING