Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia.

@article{Piel2004TargetingMP,
  title={Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia.},
  author={J{\"o}rn Piel and Dequan Hui and Nobuhiro Fusetani and Shigeki Matsunaga},
  journal={Environmental microbiology},
  year={2004},
  volume={6 9},
  pages={921-7}
}
Bacterial type I polyketide synthases (PKSs) produce a wide range of biomedically important secondary metabolites. These enzymes possess a modular structure that can be genetically re-engineered to yield novel drug candidates not found in nature. Recently, we have reported the putative pederin PKS from an uncultured bacterial symbiont of Paederus fuscipes beetles. It belongs to an architecturally unusual PKS group, the members of which contain iteratively acting acyltransferases that are not… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Nonribosomal peptides from marine sponges

  • S. Matsunaga, N. Fusetani
  • Curr Organic Chem
  • 2003
2 Excerpts

Similar Papers

Loading similar papers…