Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment

@inproceedings{Voss2018TargetingMT,
  title={Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment},
  author={Marise R. Heerma van Voss and F. Vesuna and Guus Martinus Bol and Junaid Afzal and Saritha Tantravedi and Yehudit Bergman and Kai Kammers and Mohamed Lehar and Reem A Malek and Matthew Ballew and Natalie ter Hoeve and Diane S. Abou and Daniel L. J. Thorek and Cynthia A. Berlinicke and Meysam Yazdankhah and Debasish Sinha and Anne T. Le and Riezaah Abrahams and Phuoc T Tran and Paul J van Diest and Vijayalakshmi Raman},
  booktitle={Oncogene},
  year={2018}
}
DDX3 is a DEAD box RNA helicase with oncogenic properties. RK-33 is developed as a small-molecule inhibitor of DDX3 and showed potent radiosensitizing activity in preclinical tumor models. This study aimed to assess DDX3 as a target in breast cancer and to elucidate how RK-33 exerts its anti-neoplastic effects. High DDX3 expression was present in 35% of breast cancer patient samples and correlated with markers of aggressiveness and shorter survival. With a quantitative proteomics approach, we… CONTINUE READING
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