Targeting mitochondrial apoptosis by betulinic acid in human cancers.

  title={Targeting mitochondrial apoptosis by betulinic acid in human cancers.},
  author={Simone Fulda and Guido Kroemer},
  journal={Drug discovery today},
  volume={14 17-18},
Betulinic acid (BA) is a naturally occurring pentacyclic triterpene that exhibits a variety of biological activities including potent antitumor properties. This anticancer activity has been linked to its ability to directly trigger mitochondrial membrane permeabilization, a central event in the apoptotic process that seals the cell's fate. In contrast to the potent cytotoxicity of BA against a variety of cancer types, non-neoplastic cells as well as normal tissue remain relatively resistant to… CONTINUE READING

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