Targeting mitochondria for cancer therapy

  title={Targeting mitochondria for cancer therapy},
  author={S. Fulda and L. Galluzzi and G. Kroemer},
  journal={Nature Reviews Drug Discovery},
  • S. Fulda, L. Galluzzi, G. Kroemer
  • Published 2010
  • Biology, Medicine
  • Nature Reviews Drug Discovery
  • Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of lethal signal transduction pathways converge on mitochondria to cause the permeabilization of the mitochondrial outer membrane, leading to the cytosolic release of pro-apoptotic proteins and to the impairment of the bioenergetic functions of mitochondria. The mitochondrial metabolism of cancer cells is deregulated owing to the use of glycolytic intermediates, which are normally destined for oxidative… CONTINUE READING
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