Targeting minimal residual disease: a path to cure?

  title={Targeting minimal residual disease: a path to cure?},
  author={Marlise R. Luskin and Mark A. Murakami and Scott R. Manalis and David M. Weinstock},
  journal={Nature Reviews Cancer},
Therapeutics that block kinases, transcriptional modifiers, immune checkpoints and other biological vulnerabilities are transforming cancer treatment. As a result, many patients achieve dramatic responses, including complete radiographical or pathological remission, yet retain minimal residual disease (MRD), which results in relapse. New functional approaches can characterize clonal heterogeneity and predict therapeutic sensitivity of MRD at a single-cell level. Preliminary evidence suggests… CONTINUE READING

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