Targeting microtubules for cancer chemotherapy.

@article{Zhou2005TargetingMF,
  title={Targeting microtubules for cancer chemotherapy.},
  author={Jun Zhou and Paraskevi Giannakakou},
  journal={Current medicinal chemistry. Anti-cancer agents},
  year={2005},
  volume={5 1},
  pages={
          65-71
        }
}
Chemical compounds that interfere with microtubules such as the vinca alkaloids and taxanes are important chemotherapeutic agents for the treatment of cancer. As our knowledge of microtubule-targeting drugs increases, we realize that the mechanism underlying the anti-cancer activity of these agents may mainly lie in their inhibitory effects on spindle microtubule dynamics, rather than in their effects on microtubule polymer mass. There is increasing evidence showing that even minor alteration… CONTINUE READING

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