Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells

@article{Yu2012TargetingMA,
  title={Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells},
  author={Yun Yu and Lili Yang and Minghong Zhao and Shan Zhu and Rui Kang and Philip E. Vernon and Dan Feng Tang and Liu Cao},
  journal={Leukemia},
  year={2012},
  volume={26},
  pages={1752-1760}
}
A major advancement in the treatment of chronic myeloid leukemia (CML) has been the development of imatinib and other BCR-ABL tyrosine kinase inhibitors. MicroRNAs (miRNAs) are small RNA molecules that influence gene expression by post-transcriptional regulation of messenger RNA. It is not yet clear how miRNAs are able to regulate the effectiveness of imatinib in CML. Here, we show that imatinib markedly inhibits expression of miR-30a in human CML cells. miR-30a is a potent inhibitor of… CONTINUE READING