Targeting metastatic melanoma.
@article{Poust2008TargetingMM, title={Targeting metastatic melanoma.}, author={Jamie Poust}, journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists}, year={2008}, volume={65 24 Suppl 9}, pages={ S9-S15 } }
PURPOSE
New medications and combination treatment strategies for patients with metastatic melanoma are discussed.
SUMMARY
Bcl-2 is an inhibitor of apoptosis that is overexpressed in approximately 80% of melanoma cell lines and is believed to contribute to the development of resistance to cytotoxic chemotherapy in patients with melanoma. Oblimersen, an antisense oligonucleotide that stops the translation of Bcl-2 mRNA to protein, significantly improved progression-free survival when…
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