Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors.

  title={Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors.},
  author={Callista B. Harper and Michel Robert Popoff and Adam McCluskey and Phillip J Robinson and Fr{\'e}d{\'e}ric A Meunier},
  journal={Trends in cell biology},
  volume={23 2},
Many pathogens hijack existing endocytic trafficking pathways to exert toxic effects in cells. Dynamin controls various steps of the intoxication process used by numerous pathogenic bacteria, viruses, and toxins. Targeting dynamin with pharmaceutical compounds may therefore have prophylactic potential. Here we review the growing number of pathogens requiring dynamin-dependent trafficking to intoxicate cells, outline the mode of internalization that leads to their pathogenicity, and highlight… CONTINUE READING

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