Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells.

@article{Mondesire2004TargetingMT,
  title={Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells.},
  author={Wallace H Mondesire and Weiguo Jian and Haixia Zhang and Joe Ensor and Mien-Chie Hung and Gordon B. Mills and Funda Meric-Bernstam},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 20},
  pages={7031-42}
}
PURPOSE The serine-threonine kinase mammalian target of rapamycin has emerged as a potential target for cancer therapy. Rapamycin and rapamycin analogs are undergoing clinical trials and have induced clinical responses in a subgroup of patients. Rapamycin has also been reported to enhance the efficacy of several cytotoxic agents. The aim of this study was… CONTINUE READING