Targeting malaria virulence and remodeling proteins to the host erythrocyte.


To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to approximately 8% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials.

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@article{Marti2004TargetingMV, title={Targeting malaria virulence and remodeling proteins to the host erythrocyte.}, author={Matthias Marti and R. T. Good and Melanie Rug and Ellen Knuepfer and Alan F Cowman}, journal={Science}, year={2004}, volume={306 5703}, pages={1930-3} }