Targeting mTOR to Overcome Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer Cells

@inproceedings{Fei2013TargetingMT,
  title={Targeting mTOR to Overcome Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer Cells},
  author={Shi-jiang Fei and Xuchao Zhang and Song Dong and Hua Cheng and Yi-fang Zhang and Ling Huang and Hai-yu Zhou and Zhi Xie and Zhi-hong Chen and Yi-Long Wu},
  booktitle={PloS one},
  year={2013}
}
AIMS Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown dramatic clinical benefits in advanced non-small cell lung cancer (NSCLC); however, resistance remains a serious problem in clinical practice. The present study analyzed mTOR-associated signaling-pathway differences between the EGFR TKI-sensitive and -resistant NSCLC cell lines and investigated the feasibility of targeting mTOR with specific mTOR inhibitor in EGFR TKI resistant NSCLC cells. METHODS We… CONTINUE READING
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