Targeting lymphatic vessel functions through tyrosine kinases

  title={Targeting lymphatic vessel functions through tyrosine kinases},
  author={Steven P Williams and Tara Karnezis and Marc G. Achen and Steven A Stacker},
  booktitle={Journal of angiogenesis research},
The lymphatic vascular system is actively involved in tissue fluid homeostasis, immune surveillance and fatty acid transport. Pathological conditions can arise from injury to the lymphatics, or they can be recruited in the context of cancer to facilitate metastasis. Protein tyrosine kinases are central players in signal transduction networks and regulation of cell behavior. In the lymphatic endothelium, tyrosine kinases are involved in processes such as the maintenance of existing lymphatic… CONTINUE READING


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