Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?

@article{Belmonte2016TargetingLS,
  title={Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?},
  author={Miriam Belmonte and Catherine Hoofd and Andrew P. Weng and Vincenzo Giambra},
  journal={Current oncology},
  year={2016},
  volume={23 1},
  pages={34-41}
}
T-Cell acute lymphoblastic leukemia (t-all) is a malignancy of white blood cells, characterized by an uncontrolled accumulation of T-cell progenitors. During leukemic progression, immature T cells grow abnormally and crowd into the bone marrow, preventing it from making normal blood cells and spilling out into the bloodstream. Recent studies suggest that only discrete cell populations that possess the ability to recreate the entire tumour might be responsible for the initiation and propagation… CONTINUE READING
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