Targeting lentiviral vectors to specific cell types in vivo.

@article{Yang2006TargetingLV,
  title={Targeting lentiviral vectors to specific cell types in vivo.},
  author={Lili Yang and Leslie Bailey and David Baltimore and Pin Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 31},
  pages={11479-84}
}
We have developed an efficient method to target lentivirus-mediated gene transduction to a desired cell type. It involves incorporation of antibody and fusogenic protein as two distinct molecules into the lentiviral surface. The fusogen is constructed by modifying viral envelope proteins, so that they lack the ability to bind to their cognate receptor but still retain the ability to trigger pH-dependent membrane fusion. Thus, the specificity of such a lentiviral vector is solely determined by… CONTINUE READING

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Retroviruses (Cold Spring Harbor

  • J. M. Coffin, S. H. Hughes, H. E. Varmus
  • 1997

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