Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

@article{Xie2014TargetingLD,
  title={Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.},
  author={Han Xie and Jun-ichi Hanai and Jian-Guo Ren and Lev M Kats and Kerri Burgess and Parul Bhargava and Sabina Signoretti and Julia Billiard and Kevin J Duffy and Aaron K. Grant and Xiaoen Wang and Pawel K. Lorkiewicz and Sabrina Schatzman and Michael Bousamra and Andrew N. Lane and Richard M. Higashi and Teresa W-M. Fan and Pier Paolo Pandolfi and Vikas P Sukhatme and Pankaj Seth},
  journal={Cell metabolism},
  year={2014},
  volume={19 5},
  pages={795-809}
}
The lactate dehydrogenase-A (LDH-A) enzyme catalyzes the interconversion of pyruvate and lactate, is upregulated in human cancers, and is associated with aggressive tumor outcomes. Here we use an inducible murine model and demonstrate that inactivation of LDH-A in mouse models of NSCLC driven by oncogenic K-RAS or EGFR leads to decreased tumorigenesis and disease regression in established tumors. We also show that abrogation of LDH-A results in reprogramming of pyruvate metabolism, with… CONTINUE READING

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