Targeting l1 cell adhesion molecule using lentivirus-mediated short hairpin RNA interference reverses aggressiveness of oral squamous cell carcinoma.

@article{Hung2010TargetingLC,
  title={Targeting l1 cell adhesion molecule using lentivirus-mediated short hairpin RNA interference reverses aggressiveness of oral squamous cell carcinoma.},
  author={Shiao-Chen Hung and I H Wu and S T Hsue and Chia-Hui Liao and Hsien-Chi Wang and Pei-Hsin Chuang and Shian-Ying Sung and C C Hsieh},
  journal={Molecular pharmaceutics},
  year={2010},
  volume={7 6},
  pages={2312-23}
}
The L1 cell adhesion molecule (L1CAM) has been implicated in tumor progression of many types of cancers, but its role in oral squamous cell carcinoma (OSCC) has not been investigated. In the present study, we demonstrated overexpression of L1CAM in OSCC cells, but not in normal keratinocytes, using both clinical specimens and cell lines. This overexpression demonstrated a strong correlation with less differentiation and a higher invasion potential of cancer cells, supporting the significance of… CONTINUE READING