Targeting key steps in metastatic tumour progression.

  title={Targeting key steps in metastatic tumour progression.},
  author={Suzanne A. Eccles},
  journal={Current opinion in genetics & development},
  volume={15 1},
The key determinants of tumour progression and discriminators of benign and malignant lesions include neoangiogenesis (the induction of a new blood supply) and the capacity of malignant cells to invade and metastasise. It is now recognized that these processes can be co-ordinately regulated by the activity of specific genes -- often distinct from those involved in early oncogenesis -- and involve common signalling pathways. Cell motility and chemotaxis (the ability to respond to gradients of… CONTINUE READING

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