Targeting intrinsically disordered proteins in rational drug discovery.

Abstract

INTRODUCTION Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) have gained wide recognition over the past decade due to their versatile roles in cell physiology and pathology. A large repertoire of IDPs/IDPRs has been implicated in numerous diseases, making them potential targets for therapeutic intervention… (More)
DOI: 10.1517/17460441.2016.1107041

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