Targeting intermediary metabolism in the hypothalamus as a mechanism to regulate appetite.

@article{Lopaschuk2010TargetingIM,
  title={Targeting intermediary metabolism in the hypothalamus as a mechanism to regulate appetite.},
  author={Gary D Lopaschuk and John Reyes Ussher and Jagdip S. Jaswal},
  journal={Pharmacological reviews},
  year={2010},
  volume={62 2},
  pages={237-64}
}
The central nervous system mediates energy balance (energy intake and energy expenditure) in the body; the hypothalamus has a key role in this process. Recent evidence has demonstrated an important role for hypothalamic malonyl CoA in mediating energy balance. Malonyl CoA is generated by the carboxylation of acetyl CoA by acetyl CoA carboxylase and is then either incorporated into long-chain fatty acids by fatty acid synthase, or converted back to acetyl-CoA by malonyl CoA decarboxylase… CONTINUE READING

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